Expanding the Target Landscape by Drugging the Undruggable (R21 Clinical Trial Not Allowed
The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications for exploratory and early-stage projects that focus on undruggable target classes within intractable human disease. Applicants will identify a human disease relevant undruggable target class and develop a method or agent that is selecti
| Agency | National Institutes of Health |
|---|---|
| Status | Posted |
| Opportunity number | PAR-25-442 |
| Posted date | 06/17/2025 |
| Application deadline | Feb 17, 2028 12:00:00 AM EST |
| Award ceiling | none |
| Award floor | none |
| Who can apply | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Un |
| Assistance Listing (CFDA) | 93.350, 93.121, 93.867, 93.855, 93.865, 93.242 |
| Description | The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications for exploratory and early-stage projects that focus on undruggable target classes within intractable human disease. Applicants will identify a human disease relevant undruggable target class and develop a method or agent that is selective for one or more targets within that target class. This NOFO is intended to jumpstart research that demonstrates innovative strategies to modulate targets that cannot be addressed by established therapeutic types, furthering the development of methods and/or agents selective for undruggable target classes. |
| Agency contact | grantsinfo@nih.gov |
| Official listing | https://www.grants.gov/search-results-detail/359154 |