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INCLUDE Project: Clinical Trials Phased Awards for Down syndrome Research (R61/R33 Clinica

The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome. The purpose of this Notice of Funding Opportunity (NOFO) encourages Exploratory/Developmental Phased Innovation (R61/R33) gra

AgencyNational Institutes of Health
StatusPosted
Opportunity numberRFA-OD-27-005
Posted date05/13/2026
Application deadlineJun 15, 2028 12:00:00 AM EDT
Award ceilingnone
Award floornone
Estimated total funding3,000,000
Expected number of awards4
Who can applyRefer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Assistance Listing (CFDA)93.395, 93.866, 93.839, 93.838, 93.846, 93.840, 93.173, 93.310, 93.847, 93.837, 93.233, 93.350, 93.865
DescriptionThe NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome. The purpose of this Notice of Funding Opportunity (NOFO) encourages Exploratory/Developmental Phased Innovation (R61/R33) grant applications to support development of clinical trials to treat critical and co-occurring health conditions in individuals with Down syndrome. The proposed research aims should be milestone-driven. The total project period for an application submitted in response to this NOFO may not exceed five years. This NOFO provides support for up to two years (R61 phase) for preliminary/developmental/planning studies, followed by possible transition to clinical trial support (R33) of
Agency contactDownSyndromeINCLUDE@mail.nih.gov
Official listinghttps://www.grants.gov/search-results-detail/360655

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