doxorubicin hydrochloride
doxorubicin hydrochloride is one of 8,063 medications in the MedPlain dataset. Key details — Brand name: doxorubicin hydrochloride; Generic name: DOXORUBICIN HYDROCHLORIDE; Manufacturer: Dr. Reddy's Laboratories Inc..
| Brand name | doxorubicin hydrochloride |
|---|---|
| Generic name | DOXORUBICIN HYDROCHLORIDE |
| Manufacturer | Dr. Reddy's Laboratories Inc. |
| Used for | 1 INDICATIONS AND USAGE Doxorubicin hydrochloride liposome injection is an anthracycline topoisomerase inhibitor indicated for: Ovarian cancer : After failure of platinum-based chemotherapy ( 1.1 ) AIDS-related Kaposi’s Sarcoma : After failure of prior systemic chemotherapy or intolerance to such therapy ( 1.2 ) Multiple Myeloma : In combination with bortezomib in patients who have not previously received bortezomib and have received at least one prior therapy ( 1.3 ) 1.1 Ovarian Cancer Doxorubicin hydrochloride liposome injection is indicated for the treatment of patients with ovarian cancer whose disease has progressed or recurred after platinum-based chemotherapy. 1.2 AIDS-Related Kaposi’ |
| Dosage | 2 DOSAGE AND ADMINISTRATION Administer doxorubicin hydrochloride liposome injection at an initial rate of 1 mg/min to minimize the risk of infusion reactions. If no infusion-related reactions occur, increase rate of infusion to complete administration over 1 hour. Do not administer as bolus injection or undiluted solution ( 2 ). Ovarian cancer : 50 mg/m 2 intravenously every 4 weeks ( 2.2 ) AIDS-related Kaposi’s Sarcoma : 20 mg/m 2 intravenously every 3 weeks ( 2.3 ) Multiple Myeloma : 30 mg/m 2 |
| Warnings | WARNING: CARDIOMYOPATHY and INFUSION-RELATED REACTIONS Doxorubicin hydrochloride liposome injection can cause myocardial damage, including acute left ventricular failure. The risk of cardiomyopathy was 11% when the cumulative anthracycline dose was between 450 mg/m 2 to 550 mg/m 2 . Assess left ventricular cardiac function prior to initiation of doxorubicin hydrochloride liposome injection and during and after treatment [see Warnings and Precautions ( 5.1 )]. Serious, life-threatening, and fatal |
| Active ingredient(s) | DOXORUBICIN HYDROCHLORIDE |
| Route | INTRAVENOUS |
| Official label | https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0885dddf-727e-4692-92dd-a26c69cc278d |