Levoleucovorin Calcium (LEVOLEUCOVORIN)
Levoleucovorin Calcium (LEVOLEUCOVORIN) is one of 8,063 medications in the MedPlain dataset. Key details — Brand name: Levoleucovorin Calcium; Generic name: LEVOLEUCOVORIN; Manufacturer: Amneal Pharmaceuticals LLC.
| Brand name | Levoleucovorin Calcium |
|---|---|
| Generic name | LEVOLEUCOVORIN |
| Manufacturer | Amneal Pharmaceuticals LLC |
| Used for | 1 INDICATIONS AND USAGE Levoleucovorin injection is indicated for: rescue after high-dose methotrexate therapy in adult and pediatric patients with osteosarcoma. diminishing the toxicity associated with overdosage of folic acid antagonists or impaired methotrexate elimination in adult and pediatric patients. the treatment of adults with metastatic colorectal cancer in combination with fluorouracil. Limitations of Use Levoleucovorin injection is not indicated for pernicious anemia and megaloblastic anemia secondary to the lack of vitamin B 12 , because of the risk of progression of neurologic manifestations despite hematologic remission. Levoleucovorin injection is a folate analog indicated f |
| Dosage | 2 DOSAGE AND ADMINISTRATION For intravenous administration only. Do not administer intrathecally. ( 2.1 ) Rescue After High-Dose Methotrexate Therapy Rescue recommendations are based on methotrexate dose of 12 grams/m 2 administered by intravenous infusion over 4 hours. Initiate rescue at a dose of 7.5 mg (approximately 5 mg/m 2 ) every 6 hours, 24 hours after the beginning of methotrexate infusion. ( 2.2 ) Continue until the methotrexate level is below 5 x 10 -8 M (0.05 micromolar). Adjust dose |
| Active ingredient(s) | LEVOLEUCOVORIN CALCIUM |
| Route | INTRAVENOUS |
| Official label | https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0c67eeae-3090-473d-b712-b9a83dc77b72 |