Midodrine Hydrochloride
Midodrine Hydrochloride is one of 8,063 medications in the MedPlain dataset. Key details — Brand name: Midodrine Hydrochloride; Generic name: MIDODRINE HYDROCHLORIDE; Manufacturer: Proficient Rx LP.
| Brand name | Midodrine Hydrochloride |
|---|---|
| Generic name | MIDODRINE HYDROCHLORIDE |
| Manufacturer | Proficient Rx LP |
| Used for | INDICATIONS AND USAGE Midodrine hydrochloride tablets are indicated for the treatment of symptomatic orthostatic hypotension (OH). Because midodrine hydrochloride tablets can cause marked elevation of supine blood pressure (BP > 200 mmHg systolic), it should be used in patients whose lives are considerably impaired despite standard clinical care, including non-pharmacologic treatment (such as support stockings), fluid expansion, and lifestyle alterations. The indication is based on midodrine hydrochloride tablets' effect on increases in 1-minute standing systolic blood pressure, a surrogate marker considered likely to correspond to a clinical benefit. At present, however, clinical benefits o |
| Dosage | DOSAGE AND ADMINISTRATION The recommended dose of midodrine hydrochloride tablets is 10 mg, 3 times daily. Dosing should take place during the daytime hours when the patient needs to be upright, pursuing the activities of daily life. A suggested dosing schedule of approximately 4-hour intervals is as follows: shortly before or upon arising in the morning, midday, and late afternoon (not later than 6 P.M.). Doses may be given in 3-hour intervals, if required, to control symptoms, but not more fre |
| Warnings | WARNINGS Supine Hypertension The most potentially serious adverse reaction associated with midodrine hydrochloride tablets therapy is marked elevation of supine arterial blood pressure (supine hypertension). Systolic pressures of about 200 mmHg were seen overall in about 13.4% of patients given 10 mg of midodrine hydrochloride tablets. Systolic elevations of this degree were most likely to be observed in patients with relatively elevated pre-treatment systolic blood pressures (mean 170 mmHg). Th |
| Active ingredient(s) | MIDODRINE HYDROCHLORIDE |
| Route | ORAL |
| Official label | https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0aebf5f9-8cfa-4b77-ba40-821ce0a2b266 |