sodium phenylbutyrate
sodium phenylbutyrate is one of 8,063 medications in the MedPlain dataset. Key details — Brand name: sodium phenylbutyrate; Generic name: SODIUM PHENYLBUTYRATE; Manufacturer: GLENMARK PHARMACEUTICALS INC., USA.
| Brand name | sodium phenylbutyrate |
|---|---|
| Generic name | SODIUM PHENYLBUTYRATE |
| Manufacturer | GLENMARK PHARMACEUTICALS INC., USA |
| Used for | INDICATIONS AND USAGE Sodium phenylbutyrate tablets are indicated as adjunctive therapy in the chronic management of patients with urea cycle disorders involving deficiencies of carbamylphosphate synthetase (CPS), ornithine transcarbamylase (OTC), or argininosuccinic acid synthetase (AS). It is indicated in all patients with neonatal-onset deficiency (complete enzymatic deficiency, presenting within the first 28 days of life). It is also indicated in patients with late-onset disease (partial enzymatic deficiency, presenting after the first month of life) who have a history of hyperammonemic encephalopathy. It is important that the diagnosis be made early and treatment initiated immediately t |
| Dosage | DOSAGE AND ADMINISTRATION For oral use only. The use of sodium phenylbutyrate tablets is indicated for children weighing more than 20 kg and for adults. The usual total daily dose of sodium phenylbutyrate tablets for patients with urea cycle disorders is 450 to 600 mg/kg/day in patients weighing less than 20 kg, or 9.9 to 13.0 g/m 2 /day in larger patients. The tablets is to be taken in equally divided amounts with each meal or feeding (i.e., three to six times per day). The safety or efficacy o |
| Warnings | WARNINGS Each sodium phenylbutyrate tablet contains 62 mg of sodium (9.2% w/w) (corresponding to 124 mg of sodium per gram of sodium phenylbutyrate [12.4% w/w]). Sodium phenylbutyrate should be used with great care, if at all, in patients with congestive heart failure or severe renal insufficiency, and in clinical states in which there is sodium retention with edema. Because sodium phenylbutyrate is metabolized in the liver and kidney, and phenylacetylglutamine is primarily excreted by the kidne |
| Active ingredient(s) | SODIUM PHENYLBUTYRATE |
| Route | ORAL |
| Official label | https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0c76d25b-abac-41a3-a547-4fa4796bf7a4 |