Axonal Tension as a Driver of Cortical Fold Placement and Compact Wiring — NSF Award to University of Notre Dame (IN, $382,209)
This project investigates how physical forces, specifically axonal tension or the pulling forces exerted by nerve fibers, shape the complex folded structure of the human brain. Understanding the mechanisms behind cortical folding is crucial because brain structure and function are closely related in neurological health
| Award title | Axonal Tension as a Driver of Cortical Fold Placement and Compact Wiring |
|---|---|
| Award ID | 2421742 |
| Awardee | University of Notre Dame |
| City | NOTRE DAME |
| State | IN |
| Amount obligated | $382,209 |
| Principal investigator | Maria Holland |
| Program | Special Initiatives, BMMB-Biomech & Mechanobiology |
| Start date | 09/01/2024 |
| Abstract | This project investigates how physical forces, specifically axonal tension or the pulling forces exerted by nerve fibers, shape the complex folded structure of the human brain. Understanding the mechanisms behind cortical folding is crucial because brain structure and function are closely related in neurological health and diseases. The primary hypothesis is that axonal tension helps determine the placement of cortical folds and ensures that the axonal connections of the brain are as efficient a |
| Source | NSF Awards |
$799/mo
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