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CAREER: A cortex-basal forebrain loop enabling task-specific cognitive behavior — NSF Award to University of Chicago (IL, $715,655

Cognitive flexibility, or the ability to make different decisions to meet ever-changing demands from the environment, is essential for the survival of humans and other animals. To support this key ability, the brain needs to reorganize its activity patterns depending on the current behavioral context, but we still unde

Award titleCAREER: A cortex-basal forebrain loop enabling task-specific cognitive behavior
Award ID2609479
AwardeeUniversity of Chicago
CityCHICAGO
StateIL
Amount obligated$715,655
Principal investigatorLucas Pinto
ProgramModulation, Cross-BIO Activities
Start date10/01/2025
AbstractCognitive flexibility, or the ability to make different decisions to meet ever-changing demands from the environment, is essential for the survival of humans and other animals. To support this key ability, the brain needs to reorganize its activity patterns depending on the current behavioral context, but we still understand little about how this functional reorganization is accomplished. This project will investigate this fundamental question by asking how multiple mouse brain regions act in co
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