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CAREER: A Dynamical Systems Framework for Systemic Inflammatory Response — NSF Award to University of Chicago (IL, $675,000)

Systemic inflammatory responses are dramatic immune flares that can be triggered by causes such as infection and surgical trauma. These inflammatory responses can be lethal. The goal of this project is to develop a mathematical framework to describe these responses, using a combination of experiments in a model biologi

Award titleCAREER: A Dynamical Systems Framework for Systemic Inflammatory Response
Award ID2544186
AwardeeUniversity of Chicago
CityCHICAGO
StateIL
Amount obligated$675,000
Principal investigatorElizabeth Jerison
ProgramPHYSICS OF LIVING SYSTEMS
Start date04/01/2026
AbstractSystemic inflammatory responses are dramatic immune flares that can be triggered by causes such as infection and surgical trauma. These inflammatory responses can be lethal. The goal of this project is to develop a mathematical framework to describe these responses, using a combination of experiments in a model biological system (zebrafish) and novel Artificial Intelligence (AI) and Machine Learning (ML) tools. This project will use methods from genomics to trace the organism’s immune response a
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