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CAREER: Comprehensive Investigation of the Molecular Mechanisms of Bacterial Manganese Hom — NSF Award to Reed College (OR, $835,0

Manganese is an essential nutrient for bacteria. It helps bacteria defend against harmful molecules that are part of the human immune response. However, too much manganese is toxic. Unlike nutrients such as sugars or vitamins, bacteria cannot produce manganese. It must be imported from their environment. As a result, t

Award titleCAREER: Comprehensive Investigation of the Molecular Mechanisms of Bacterial Manganese Hom
Award ID2544698
AwardeeReed College
CityPORTLAND
StateOR
Amount obligated$835,085
Principal investigatorShivani Ahuja
ProgramMolecular Biosciences
Start date06/01/2026
AbstractManganese is an essential nutrient for bacteria. It helps bacteria defend against harmful molecules that are part of the human immune response. However, too much manganese is toxic. Unlike nutrients such as sugars or vitamins, bacteria cannot produce manganese. It must be imported from their environment. As a result, they must carefully control how much enters and leaves the cell. To maintain this balance, bacteria use specialized proteins that collaborate to reduce uptake when manganese levels
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