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CAREER: Electrically Encoded Innate Immune Sensing in Cardiomyocytes — NSF Award to North Dakota State University Fargo (ND, $570,

The ability of cells to detect viral infection and cell damage is essential for the body’s first-line immune defense and for protecting human health. Foreign or misplaced genetic material, such as viral DNA or RNA or a cell’s own nucleic acids appearing in the wrong part of a cell, serves as an important danger signal

Award titleCAREER: Electrically Encoded Innate Immune Sensing in Cardiomyocytes
Award ID2541292
AwardeeNorth Dakota State University Fargo
CityFARGO
StateND
Amount obligated$570,477
Principal investigatorAng Guo
ProgramCell, Dev, & Physio
Start date07/01/2026
AbstractThe ability of cells to detect viral infection and cell damage is essential for the body’s first-line immune defense and for protecting human health. Foreign or misplaced genetic material, such as viral DNA or RNA or a cell’s own nucleic acids appearing in the wrong part of a cell, serves as an important danger signal that alerts cells to these threats. This project asks a fundamental question: can electrically active cells, such as heart cells, use electrical signals to detect and respond to su
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