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CAREER: From Energy Flow to Function: A Biophysical Framework for Rational Enzyme Evolutio — NSF Award to Tulane University (LA, $

Proteins are essential to life and play central roles in medicine, biotechnology, and sustainable manufacturing. They enable critical chemical reactions that support human health, environmental processes, and industrial production. However, improving protein function remains a major challenge because current approaches

Award titleCAREER: From Energy Flow to Function: A Biophysical Framework for Rational Enzyme Evolutio
Award ID2540525
AwardeeTulane University
CityNEW ORLEANS
StateLA
Amount obligated$504,681
Principal investigatorShuaihua Gao
ProgramMolecular Biosciences
Start date06/01/2026
AbstractProteins are essential to life and play central roles in medicine, biotechnology, and sustainable manufacturing. They enable critical chemical reactions that support human health, environmental processes, and industrial production. However, improving protein function remains a major challenge because current approaches often rely on trial-and-error methods or static structural information, which do not fully capture how proteins carry out complex chemical transformations. In particular, there is
SourceNSF Awards

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