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CAREER: Impact of MRI contrast agent design on nanoscale interactions with neutrophils and — NSF Award to West Virginia University

Understanding how nanoparticle characteristics mediate their interactions with blood cells in the body is crucial to promoting their safety and effectiveness. Nanoparticles delivered to the bloodstream are surrounded by red blood cells, a variety of white blood cells, and platelets. Despite blood’s complexity, most stu

Award titleCAREER: Impact of MRI contrast agent design on nanoscale interactions with neutrophils and
Award ID2339015
AwardeeWest Virginia University Research Corporation
CityMORGANTOWN
StateWV
Amount obligated$697,973
Principal investigatorMargaret Bennewitz
ProgramNanoscale Interactions Program, EPSCoR Co-Funding
Start date04/01/2024
AbstractUnderstanding how nanoparticle characteristics mediate their interactions with blood cells in the body is crucial to promoting their safety and effectiveness. Nanoparticles delivered to the bloodstream are surrounded by red blood cells, a variety of white blood cells, and platelets. Despite blood’s complexity, most studies developing nanoparticles for imaging applications have focused on assessing off-target nanoparticle interactions with a subtype of white blood cells called macrophages. Macrop
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