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CAREER: New routes to designing dynamic protein structures — NSF Award to Research Foundation CUNY - Advanced Science Research Cen

Natural proteins perform critical functions in our bodies. Proteins can be designed to perform new functions that help society. For example, designed proteins could detect diseases, transport drugs, generate clean fuels, and defuse toxins. However, designed proteins perform worse than natural ones. This project aims to

Award titleCAREER: New routes to designing dynamic protein structures
Award ID2543428
AwardeeResearch Foundation CUNY - Advanced Science Research Center
CityNEW YORK
StateNY
Amount obligated$763,328
Principal investigatorDaniel Keedy
ProgramMolecular Biosciences
Start date06/15/2026
AbstractNatural proteins perform critical functions in our bodies. Proteins can be designed to perform new functions that help society. For example, designed proteins could detect diseases, transport drugs, generate clean fuels, and defuse toxins. However, designed proteins perform worse than natural ones. This project aims to use lessons from natural proteins to produce better designed proteins. This will be done by testing whether existing designed proteins move differently than natural ones. The work
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