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CAREER: Structure-Aware Protein Language Models for Decoding Immune Recognition — NSF Award to Icahn School of Medicine at Mount S

The immune system protects the body by recognizing abnormal cells and infectious threats, yet the molecular rules that allow immune cells to distinguish dangerous targets from healthy cells remain poorly understood. This project will develop new computational approaches to better understand immune recognition, a fundam

Award titleCAREER: Structure-Aware Protein Language Models for Decoding Immune Recognition
Award ID2542232
AwardeeIcahn School of Medicine at Mount Sinai
CityNEW YORK
StateNY
Amount obligated$204,412
Principal investigatorDiego Chowell
ProgramFET-Fndtns of Emerging Tech
Start date07/01/2026
AbstractThe immune system protects the body by recognizing abnormal cells and infectious threats, yet the molecular rules that allow immune cells to distinguish dangerous targets from healthy cells remain poorly understood. This project will develop new computational approaches to better understand immune recognition, a fundamental problem in biology with broad relevance to health, cancer immunotherapy, autoimmunity, and future biomedical discovery. The project will also advance computing by developing
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