Collaborative Research: DMS/NIGMS 1: Understanding genomic organization in the nucleus via — NSF Award to University of Pennsylvan
Addressing the questions of how the two-meter-long human DNA fits into the space of a cell's nucleus (~20 um) and how it is organized within this space has been among the major mysteries of cell biology. DNA is packaged into the nucleus in the form of chromatin, consisting of a complex between DNA and histone proteins.
| Award title | Collaborative Research: DMS/NIGMS 1: Understanding genomic organization in the nucleus via |
|---|---|
| Award ID | 2347834 |
| Awardee | University of Pennsylvania |
| City | PHILADELPHIA |
| State | PA |
| Amount obligated | $200,000 |
| Principal investigator | Vivek Shenoy |
| Program | NIGMS |
| Start date | 07/01/2024 |
| Abstract | Addressing the questions of how the two-meter-long human DNA fits into the space of a cell's nucleus (~20 um) and how it is organized within this space has been among the major mysteries of cell biology. DNA is packaged into the nucleus in the form of chromatin, consisting of a complex between DNA and histone proteins. DNA wrapped in compacted histones is thought of as “repressed” and “inaccessible”, and thus chromatin compaction plays a critical role in regulating gene activity. Current chromat |
| Source | NSF Awards |
$799/mo
Try NSFGrants →