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Collaborative Research: Engineering spatiotemporal temperature control of solvated noble-m — NSF Award to University of Rhode Isla

The use of light-activated gold nanoparticles for thermal ablation of cancerous tissue and localized thermally-activated drug and gene delivery systems has been extensively investigated. However, these therapeutic approaches have stalled at the preclinical stage because the nanoparticle temperature cannot be controlled

Award titleCollaborative Research: Engineering spatiotemporal temperature control of solvated noble-m
Award ID2430794
AwardeeUniversity of Rhode Island
CityKINGSTON
StateRI
Amount obligated$174,936
Principal investigatorAshutosh Giri
ProgramTTP-Thermal Transport Process
Start date01/01/2025
AbstractThe use of light-activated gold nanoparticles for thermal ablation of cancerous tissue and localized thermally-activated drug and gene delivery systems has been extensively investigated. However, these therapeutic approaches have stalled at the preclinical stage because the nanoparticle temperature cannot be controlled precisely, which leads to effects on tissue away from the therapeutic target. The conversion of light to heat inside the nanoparticles is efficient and fast, which means the key p
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