Collaborative Research: Imaging the transition: Temporal control of zygotic genome activat — NSF Award to Dartmouth College (NH, $
Early embryonic development is characterized by a dramatic transition from cellular dependence on RNAs that were in the egg prior to fertilization to RNAs produced by the embryo itself. This process is known as zygotic genome activation (ZGA). The timing of ZGA is linked to changes in cell size, specifically the ratio
| Award title | Collaborative Research: Imaging the transition: Temporal control of zygotic genome activat |
|---|---|
| Award ID | 2534079 |
| Awardee | Dartmouth College |
| City | HANOVER |
| State | NH |
| Amount obligated | $690,177 |
| Principal investigator | Amanda Amodeo |
| Program | Molecular Biosciences |
| Start date | 05/01/2026 |
| Abstract | Early embryonic development is characterized by a dramatic transition from cellular dependence on RNAs that were in the egg prior to fertilization to RNAs produced by the embryo itself. This process is known as zygotic genome activation (ZGA). The timing of ZGA is linked to changes in cell size, specifically the ratio of nuclear content (DNA) to cytoplasmic volume (also known as the nuclear-to-cytoplasmic or N/C ratio), which increases as cells replicate their DNA without growth. How cells measu |
| Source | NSF Awards |
$799/mo
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