Collaborative Research: RUI: Life without lipopolysaccharide- Synthesis of ceramide phosph — NSF Award to Rutgers University Camde
Gram-negative bacteria are enclosed by two membranes with different compositions. The outer membrane normally has LPS, a lipid with sugars attached to it. We recently discovered that a model bacterium can survive without LPS if it produces CPG2, a type of ceramide lipid. This shows the importance of ceramides in bacter
| Award title | Collaborative Research: RUI: Life without lipopolysaccharide- Synthesis of ceramide phosph |
|---|---|
| Award ID | 2515532 |
| Awardee | Rutgers University Camden |
| City | CAMDEN |
| State | NJ |
| Amount obligated | $791,029 |
| Principal investigator | Eric Klein |
| Program | Cellular Dynamics and Function |
| Start date | 09/01/2025 |
| Abstract | Gram-negative bacteria are enclosed by two membranes with different compositions. The outer membrane normally has LPS, a lipid with sugars attached to it. We recently discovered that a model bacterium can survive without LPS if it produces CPG2, a type of ceramide lipid. This shows the importance of ceramides in bacterial biology and provides an opportunity to study alternative modes of outer membrane construction in bacteria. The proposed research is anticipated to discover how CPG2 is made and |
| Source | NSF Awards |
$799/mo
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