Defining Barriers to Nucleosome Mobility through Single-Molecule Manipulation — NSF Award to Johns Hopkins University (MD, $1,399,
Chromosomes consist of long DNA strands that hold the information coding for life. Chromosomes are extensively wrapped into spool-like structures called nucleosomes in all plants and animals, including humans. Nucleosome packaging provides the sophisticated levels of control needed for turning genes on and off and regu
| Award title | Defining Barriers to Nucleosome Mobility through Single-Molecule Manipulation |
|---|---|
| Award ID | 2530651 |
| Awardee | Johns Hopkins University |
| City | BALTIMORE |
| State | MD |
| Amount obligated | $1,399,593 |
| Principal investigator | Gregory Bowman |
| Program | Chemistry of Life Processes, Genetic Mechanisms, Molecular Biophysics |
| Start date | 09/01/2025 |
| Abstract | Chromosomes consist of long DNA strands that hold the information coding for life. Chromosomes are extensively wrapped into spool-like structures called nucleosomes in all plants and animals, including humans. Nucleosome packaging provides the sophisticated levels of control needed for turning genes on and off and regulating cellular functions. This project is focused on understanding how nucleosomes slide along DNA and enable dynamic changes in its packaging. Nucleosomes can be actively moved b |
| Source | NSF Awards |
$799/mo
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