Determining how the evolution of the coronavirus macrodomain contributes to its biochemica — NSF Award to University of Kansas Cen
This project explores how macrodomain proteins have evolved to balance their different multiple biochemical activities. Macrodomains are ancient enzymes that bind to and remove ADP-ribose, an important post-translation modification that is critical in several cellular stress responses, including DNA damage, ER stress,
| Award title | Determining how the evolution of the coronavirus macrodomain contributes to its biochemica |
|---|---|
| Award ID | 2515959 |
| Awardee | University of Kansas Center for Research Inc |
| City | LAWRENCE |
| State | KS |
| Amount obligated | $1,000,000 |
| Principal investigator | Anthony Fehr |
| Program | Cross-BIO Activities, Genetic Mechanisms |
| Start date | 08/01/2025 |
| Abstract | This project explores how macrodomain proteins have evolved to balance their different multiple biochemical activities. Macrodomains are ancient enzymes that bind to and remove ADP-ribose, an important post-translation modification that is critical in several cellular stress responses, including DNA damage, ER stress, and virus infection. These enzymes are conserved through all domains of life, including archaea, bacteria, eukaryotes, and viruses, indicating that they are critical for multiple c |
| Source | NSF Awards |
$799/mo
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