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Dissecting metabolite-mediated gene regulation through dynamic interactions between an enz — NSF Award to Purdue University (IN, $

This project will investigate how small molecules produced in plant cells regulate gene activity. Plants produce a vast diversity of metabolites that are essential for growth, environmental responses, and the synthesis of valuable natural products, but their production must be tightly regulated in cells to avoid wastin

Award titleDissecting metabolite-mediated gene regulation through dynamic interactions between an enz
Award ID2545054
AwardeePurdue University
CityWEST LAFAYETTE
StateIN
Amount obligated$1,200,000
Principal investigatorYing Li
ProgramMolecular Biosciences
Start date06/01/2026
AbstractThis project will investigate how small molecules produced in plant cells regulate gene activity. Plants produce a vast diversity of metabolites that are essential for growth, environmental responses, and the synthesis of valuable natural products, but their production must be tightly regulated in cells to avoid wasting energy or overaccumulation of harmful compounds. This research focuses on how small-molecule metabolites trigger feedback regulation of gene expression, a fundamental but poorly
SourceNSF Awards

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