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EAGER: Enzymatic Perturbation Specificity Test for Self-Validating, In-Situ Regenerable Na — NSF Award to University of California

Wearable and point of care biosensors can deliver earlier and more personalized health information than laboratory tests. However, many sensors cannot verify that the signals they produce truly come from a targeted molecule, especially in a complex and changing biofluid. This project will develop a built in “specificit

Award titleEAGER: Enzymatic Perturbation Specificity Test for Self-Validating, In-Situ Regenerable Na
Award ID2615022
AwardeeUniversity of California-Irvine
CityIRVINE
StateCA
Amount obligated$210,000
Principal investigatorRahim Esfandyarpour
ProgramBIOSENS-Biosensing
Start date05/01/2026
AbstractWearable and point of care biosensors can deliver earlier and more personalized health information than laboratory tests. However, many sensors cannot verify that the signals they produce truly come from a targeted molecule, especially in a complex and changing biofluid. This project will develop a built in “specificity check” for sensors operating under the skin. The Enzymatic Perturbation Specificity Test (EPST) will measure a sample and then measure it again after an enzyme briefly converts o
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