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EAGER: Multimodal AI for Elucidating Genome Structure-Function Relationships in Human Brai — NSF Award to Massachusetts Institute

The human brain comprises a remarkable variety of cell types that collectively support sensation, cognition, and behavior. This diversity arises not from differences in genetic code, but from how DNA is physically organized and regulated in each cell. Understanding the 3D structure of the genome – and how it controls w

Award titleEAGER: Multimodal AI for Elucidating Genome Structure-Function Relationships in Human Brai
Award ID2541725
AwardeeMassachusetts Institute of Technology
CityCAMBRIDGE
StateMA
Amount obligated$300,000
Principal investigatorBin Zhang
ProgramCross-BIO Activities
Start date08/15/2025
AbstractThe human brain comprises a remarkable variety of cell types that collectively support sensation, cognition, and behavior. This diversity arises not from differences in genetic code, but from how DNA is physically organized and regulated in each cell. Understanding the 3D structure of the genome – and how it controls which genes are active in different brain cells – is essential for advancing neuroscience, regenerative medicine, and genome engineering. This project will use AI to investigate how
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