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Genetics and Biosynthesis of Novel Forms of Methanobactin — NSF Award to Regents of the University of Michigan - Ann Arbor (MI, $5

Trace metals, including copper, are essential for all forms of life. Copper, however, can be toxic at high levels. The human body must carefully and continuously remove excess copper. Wilson Disease is a congenital disorder where the body cannot control internal copper levels. This results in serious and irreversible d

Award titleGenetics and Biosynthesis of Novel Forms of Methanobactin
Award ID2418164
AwardeeRegents of the University of Michigan - Ann Arbor
CityANN ARBOR
StateMI
Amount obligated$592,188
Principal investigatorJeremy Semrau
ProgramCellular & Biochem Engineering
Start date09/01/2024
AbstractTrace metals, including copper, are essential for all forms of life. Copper, however, can be toxic at high levels. The human body must carefully and continuously remove excess copper. Wilson Disease is a congenital disorder where the body cannot control internal copper levels. This results in serious and irreversible damage to the liver and brain that is fatal if untreated. Current FDA-approved therapies are of no use if acute organ damage has already occurred, and in some patients, simply do no
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