Improving T cell Production through Mechanometabolism and Control of Nutrient Availability — NSF Award to Columbia University (NY,
The ability of T lymphocytes, cells with key roles in adaptive immunity, to patrol the body, respond to pathogens, and coordinate activities of organs has led to their use as a “living drug”, most prominently against cancer. However, reliable manufacture of these cells remains a challenge, which has inspired the develo
| Award title | Improving T cell Production through Mechanometabolism and Control of Nutrient Availability |
|---|---|
| Award ID | 2416900 |
| Awardee | Columbia University |
| City | NEW YORK |
| State | NY |
| Amount obligated | $515,885 |
| Principal investigator | Lance Kam |
| Program | BMMB-Biomech & Mechanobiology |
| Start date | 11/01/2024 |
| Abstract | The ability of T lymphocytes, cells with key roles in adaptive immunity, to patrol the body, respond to pathogens, and coordinate activities of organs has led to their use as a “living drug”, most prominently against cancer. However, reliable manufacture of these cells remains a challenge, which has inspired the development of biomaterials that promote desirable qualities of these cells. This project focuses on using the stiffness of such materials to improve T cell production, focusing on the g |
| Source | NSF Awards |
$799/mo
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