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Interrogating the Fundamental Mechanisms of Mechanical Neuromodulation at the Nanoscale — NSF Award to University of Illinois at U

Brain disorders affect millions of people worldwide, yet effective treatment options remain limited. Ultrasound neuromodulation is a promising technique that uses sound waves to gently influence brain activity without surgery. However, scientists do not fully understand how ultrasound affects individual brain cells, wh

Award titleInterrogating the Fundamental Mechanisms of Mechanical Neuromodulation at the Nanoscale
Award ID2528704
AwardeeUniversity of Illinois at Urbana-Champaign
CityURBANA
StateIL
Amount obligated$395,787
Principal investigatorYang Zhao
ProgramBioP-Biophotonics
Start date05/01/2026
AbstractBrain disorders affect millions of people worldwide, yet effective treatment options remain limited. Ultrasound neuromodulation is a promising technique that uses sound waves to gently influence brain activity without surgery. However, scientists do not fully understand how ultrasound affects individual brain cells, which limits its safe and effective use in medicine. This project will uncover how mechanical forces created by ultrasound interact with neurons at length scales smaller than a singl
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