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Lysosome-Directed Strategies to Improve the Success of Neural Interfaces — NSF Award to University of Pittsburgh (PA, $550,000)

Tiny electrodes placed in the brain can help doctors treat conditions like Parkinson's disease, epilepsy, and paralysis. These devices, called brain-computer interfaces (BCIs), can let a paralyzed person move a robotic arm or speak through a computer. For BCIs to function, the tissue around the newly implanted electrod

Award titleLysosome-Directed Strategies to Improve the Success of Neural Interfaces
Award ID2552758
AwardeeUniversity of Pittsburgh
CityPITTSBURGH
StatePA
Amount obligated$550,000
Principal investigatorKirill Kiselyov
ProgramEngineering of Biomed Systems
Start date06/15/2026
AbstractTiny electrodes placed in the brain can help doctors treat conditions like Parkinson's disease, epilepsy, and paralysis. These devices, called brain-computer interfaces (BCIs), can let a paralyzed person move a robotic arm or speak through a computer. For BCIs to function, the tissue around the newly implanted electrode must heal and form a stable connection with it. Half of the BCIs stop functioning within a year because brain tissue around the device does not heal and becomes inflamed. Electro
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