MFB: Programmable RNA Targeting and Engineering using Pentatricopeptide Repeat Proteins — NSF Award to Columbia University (NY, $1
With this award, the Molecular Foundations for Biotechnology (MFB) Program is funding Drs. Chaolin Zhang and Harris H. Wang from Columbia University to engineer modular proteins that can be programmed to precisely edit sequences of RNA messages or control the expression of genes encoded in these messenger RNAs in human
| Award title | MFB: Programmable RNA Targeting and Engineering using Pentatricopeptide Repeat Proteins |
|---|---|
| Award ID | 2515799 |
| Awardee | Columbia University |
| City | NEW YORK |
| State | NY |
| Amount obligated | $1,200,000 |
| Principal investigator | Chaolin Zhang |
| Program | CHEMISTRY PROJECTS, OFFICE OF MULTIDISCIPLINARY AC, Cross-BIO Activities, Genetic Mechanisms |
| Start date | 09/01/2025 |
| Abstract | With this award, the Molecular Foundations for Biotechnology (MFB) Program is funding Drs. Chaolin Zhang and Harris H. Wang from Columbia University to engineer modular proteins that can be programmed to precisely edit sequences of RNA messages or control the expression of genes encoded in these messenger RNAs in human cells. This project adapts a unique class of plant proteins, called pentatricopeptide repeat (PPR) proteins that naturally recognize RNA sequences through a modular code. Such pro |
| Source | NSF Awards |
$799/mo
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