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Multiplex Next Generation Sequencing of Glycans and Nucleic Acids for Accelerating the Dev — NSF Award to University of California

Glycans consist of long branching chains of different sugars. They adorn proteins of all types. Some viruses use glycans to enhance the probability of infection. Some tumors hide from the immune system by using “stealth” glycoproteins on their surfaces. Most of the top drugs by revenue are glycoproteins, and their glyc

Award titleMultiplex Next Generation Sequencing of Glycans and Nucleic Acids for Accelerating the Dev
Award ID2335957
AwardeeUniversity of California-San Diego
CityLA JOLLA
StateCA
Amount obligated$609,503
Principal investigatorNathan Lewis
ProgramCellular & Biochem Engineering
Start date07/15/2024
AbstractGlycans consist of long branching chains of different sugars. They adorn proteins of all types. Some viruses use glycans to enhance the probability of infection. Some tumors hide from the immune system by using “stealth” glycoproteins on their surfaces. Most of the top drugs by revenue are glycoproteins, and their glycans affect drug safety and efficacy. This places a premium on making sure that their glycans are well-characterized and carefully managed. The complexity of glycan structures makes
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