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NSF-DBT: Exploiting codon usage bias to maximize the productivity of recombinant Komagatae — NSF Award to Tufts University (MA, $5

Pichia pastoris is a food-safe yeast. It is widely used as a model organism for basic biological research and in a variety of biomanufacturing applications. Nevertheless, how to maximize the productivity of this microbe is not well understood. This project will focus on understanding how this yeast allocates its resour

Award titleNSF-DBT: Exploiting codon usage bias to maximize the productivity of recombinant Komagatae
Award ID2427905
AwardeeTufts University
CityMEDFORD
StateMA
Amount obligated$545,000
Principal investigatorNikhil Nair
ProgramCellular & Biochem Engineering
Start date05/15/2025
AbstractPichia pastoris is a food-safe yeast. It is widely used as a model organism for basic biological research and in a variety of biomanufacturing applications. Nevertheless, how to maximize the productivity of this microbe is not well understood. This project will focus on understanding how this yeast allocates its resources for protein synthesis. The results can be used to maximize productivity. The outcomes could enable significant advances in food, biomedical, and scientific applications of this
SourceNSF Awards

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