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Packaging, Targeting, and Replication of Virus-derived RNA Replicons — NSF Award to University of California-Los Angeles (CA, $763

In order to better control and treat viral outbreaks such as the current COVID-19 pandemic, it is necessary to better understand on a molecular level the life cycles of RNA viruses – how they get into and out of their host cells, and how they replicate in those cells. This project focuses on three of the simplest and b

Award titlePackaging, Targeting, and Replication of Virus-derived RNA Replicons
Award ID2103700
AwardeeUniversity of California-Los Angeles
CityLOS ANGELES
StateCA
Amount obligated$763,871
Principal investigatorWilliam Gelbart
ProgramGenetic Mechanisms
Start date07/01/2021
AbstractIn order to better control and treat viral outbreaks such as the current COVID-19 pandemic, it is necessary to better understand on a molecular level the life cycles of RNA viruses – how they get into and out of their host cells, and how they replicate in those cells. This project focuses on three of the simplest and best characterized RNA viruses – ones, like SARS-2, whose genomes are single-stranded RNA that the target cell translates into viral proteins. This project aims to discover fundamen
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