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Platelet-like Synthetic Cells with Shape Change, Triggered Secretion and Functional Adhesi — NSF Award to University of Texas at A

This project develops synthetic cells that mimic the essential functions of biological platelets – shape transformation, biochemical secretion, and mechanical adhesion – to promote blood clotting in a programmable and externally controllable manner. Platelets are among the simplest cells in the human body, yet they per

Award titlePlatelet-like Synthetic Cells with Shape Change, Triggered Secretion and Functional Adhesi
Award ID2530428
AwardeeUniversity of Texas at Austin
CityAUSTIN
StateTX
Amount obligated$1,332,516
Principal investigatorBrian Belardi
ProgramSystems and Synthetic Biology
Start date08/15/2025
AbstractThis project develops synthetic cells that mimic the essential functions of biological platelets – shape transformation, biochemical secretion, and mechanical adhesion – to promote blood clotting in a programmable and externally controllable manner. Platelets are among the simplest cells in the human body, yet they perform a complex and highly coordinated sequence of actions in response to vascular injury. The proposed synthetic cells emulate these sophisticated behaviors using light-activated c
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