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Rational Design and Fundamental Understanding of Multimodal Amyloid Probes — NSF Award to University of Texas at San Antonio (TX,

The hallmark of many debilitating diseases, such as Alzeimer’s disease (AD) and type II diabetes (T2D), is the presence of abnormal masses/aggregates of proteins termed “amyloids”. These amyloids, in which composition is disease dependent, are generally considered to be ideal markers for disease diagnosis and therapeut

Award titleRational Design and Fundamental Understanding of Multimodal Amyloid Probes
Award ID2603320
AwardeeUniversity of Texas at San Antonio
CitySAN ANTONIO
StateTX
Amount obligated$153,759
Principal investigatorJie Zheng
ProgramBIOSENS-Biosensing
Start date12/01/2025
AbstractThe hallmark of many debilitating diseases, such as Alzeimer’s disease (AD) and type II diabetes (T2D), is the presence of abnormal masses/aggregates of proteins termed “amyloids”. These amyloids, in which composition is disease dependent, are generally considered to be ideal markers for disease diagnosis and therapeutic intervention. Unfortunately, existing probes are limited in that they are only able to detect the presence of a single targeted amyloid protein. This project will develop a new
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