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RUI: Analyzing the interactions and functional conservation of orphan genes required for m — NSF Award to College of the Holy Cros

In many insects, fertilization requires thin, needle-shaped sperm to locate and enter a narrow channel on the surface of an egg. Understanding the molecular interactions required for insect fertilization could enable scientists to manipulate the reproduction of species of agricultural or biomedical relevance. To date,

Award titleRUI: Analyzing the interactions and functional conservation of orphan genes required for m
Award ID2523403
AwardeeCollege of the Holy Cross
CityWORCESTER
StateMA
Amount obligated$722,198
Principal investigatorGeoffrey Findlay
ProgramAnimal Developmental Mechanism, Genetic Mechanisms, Evolutionary Processes
Start date09/01/2025
AbstractIn many insects, fertilization requires thin, needle-shaped sperm to locate and enter a narrow channel on the surface of an egg. Understanding the molecular interactions required for insect fertilization could enable scientists to manipulate the reproduction of species of agricultural or biomedical relevance. To date, however, little is known about how insect sperm take on their needle-like shape and recognize eggs to facilitate entry. This project uses the tractable fruit fly model system to in
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