Telomere End-Protection and the Anti-Checkpoint — NSF Award to Cleveland Clinic Foundation (OH, $999,626)
The DNA of organisms from yeast to humans is packaged in linear chromosomes, the ends of which are called telomeres. When chromosomes are broken, the broken ends can be degraded or fused with other chromosomes to cause mutations and diseases such as cancer. Broken chromosomes and telomeres both present DNA ends, but te
| Award title | Telomere End-Protection and the Anti-Checkpoint |
|---|---|
| Award ID | 2530370 |
| Awardee | Cleveland Clinic Foundation |
| City | CLEVELAND |
| State | OH |
| Amount obligated | $999,626 |
| Principal investigator | Kurt Runge |
| Program | Genetic Mechanisms |
| Start date | 09/01/2025 |
| Abstract | The DNA of organisms from yeast to humans is packaged in linear chromosomes, the ends of which are called telomeres. When chromosomes are broken, the broken ends can be degraded or fused with other chromosomes to cause mutations and diseases such as cancer. Broken chromosomes and telomeres both present DNA ends, but telomeres have special DNA sequences and proteins bound to them that block degradation and fusion. The laboratory recently discovered a new way that cells can distinguish a broken DN |
| Source | NSF Awards |
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