3D-Microscopic Muscle Architecture in Cerebral Palsy
The focus of this study is to understand and define the mechanisms of the altered muscle development and growth on a microscopic level within a long-term perspective in children with cerebral palsy and to relate these findings to muscle macroscopic properties defined by muscle imaging, to neuromuscular symptoms and to
| Condition(s) | Spastic Cerebral Palsy |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | The focus of this study is to understand and define the mechanisms of the altered muscle development and growth on a microscopic level within a long-term perspective in children with cerebral palsy and to relate these findings to muscle macroscopic properties defined by muscle imaging, to neuromuscular symptoms and to treatment. This study aims to (1) evaluate intrinsic microscopic muscle properties of young growing children with CP, and (2) to evaluate these muscle properties in relation to macroscopic properties, neuromuscular symptoms and to treatment. Improved understanding of changes in microscopic muscle properties, and how they relate to macroscopic properties and to the neuromuscular symptoms as well as how they are influenced by treatment, has the potential to delineate CP phenoty |
| Who can participate | CHILDREN WITH CP Inclusion criteria * Children (boys/girls) diagnosed with predominantly spastic type of CP * Uni- or bilateral involvement * Gross Motor Function Classification Scale (GMFCS) Level I-III50 * 2 to 9 years of age * Planned for an orthopedic intervention that requires general anesthesia (botulinum toxin injections, orthopedic surgery, or diagnostic imaging such as Magnetic Resonance Imaging \[MRI\], etc.) Exclusion criteria * Presence of dystonia or ataxia * Previous surgery less than 6 months at the investigated muscles * Severe co-morbidities (that are likely to prevent proper assessment, such as severe cognitive problems) TYPICALY DEVELOPING CHILDREN Inclusion criteria * Children (boys/girls) * 2 to 9 years of age * Planned for a surgical intervention that requires general |
| Ages | 2 Years to 9 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | Universitaire Ziekenhuizen KU Leuven |
| Locations | Leuven, Vlaams-Brabant, Belgium |
| Start date | 2019-05-02 |
| NCT ID | NCT06584851 |
| Official listing | https://clinicaltrials.gov/study/NCT06584851 |