A Longitudinal Study to Explore the Impact of Gut Microbiome on Brain Health in Alzheimer'
Gut microbiota dysfunction is associated with Alzheimer's disease (AD). However, the potential modulatory mechanism remains unclear. Previous studies have shown that gut-derived metabolites short-chain fatty acids (SCFAs) may be the key mediators between gut microbiota and brain, participating in the modulatory pathway
| Condition(s) | Alzheimer Disease, Gut Microbiota, Metabonomics, Magnetic Resonance Imaging |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | Gut microbiota dysfunction is associated with Alzheimer's disease (AD). However, the potential modulatory mechanism remains unclear. Previous studies have shown that gut-derived metabolites short-chain fatty acids (SCFAs) may be the key mediators between gut microbiota and brain, participating in the modulatory pathway "gut microbiota-SCFAs-brain networks". In this project, high-throughput targeted metabolomics technique will be used to explore the differences of SCFAs in the spectrum of AD, including cognitively normal individuals, subjective cognitive decline (SCD), mild cognitive impairment (MCI), and AD dementia. Then, the gut microbiome and multi-modal MRI techniques will be combined to elucidate potential interaction mechanisms of "gut microbiota-SCFAs-brain networks". Finally, based |
| Who can participate | Inclusion Criteria: * Cognitively normal group: 1. normal performance on standardized cognitive tests; 2. with no cognitive complaints or any concerns (worries). * SCD group: 1. self-experienced persistent decline in memory, rather than other domains of cognition; 2. normal performance on standardized cognitive tests; 3. failure to meet the criteria for MCI or dementia; 4. age at onset of SCD ≥ 60 years old; 5. onset of SCD within the last 5 years; 6. concerns (worries) associated with SCD; 7. feeling of worse performance than others of the same age group. * MCI group: 1. having impaired scores on both measures in at least one cognitive domain (memory, language, or speed/executive function); 2. having impaired scores in each of the three cognitive domains (memory, language, or speed/execut |
| Ages | 60 Years to 80 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | Jining Medical University |
| Locations | Jining, Shandong, China |
| Start date | 2024-01-01 |
| NCT ID | NCT06837272 |
| Official listing | https://clinicaltrials.gov/study/NCT06837272 |