A Multi-dimensional Evaluation of the Effects of Linear Accelerator X-ray Irradiation on R
This study aims to investigate the effects of linear accelerator X-ray irradiation on the structure, mechanics and functional characteristics of red blood cells recovered from patients with malignant tumors during surgery. A red blood cell damage evaluation system based on multiple-dimensional indicators is established
| Condition(s) | Erythrocyte Destruction |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | This study aims to investigate the effects of linear accelerator X-ray irradiation on the structure, mechanics and functional characteristics of red blood cells recovered from patients with malignant tumors during surgery. A red blood cell damage evaluation system based on multiple-dimensional indicators is established. Through atomic force microscopy, microfluidic chips and biochemical detection methods, the changes in red blood cell membrane structure, deformability and oxygen-carrying capacity under different irradiation doses are systematically evaluated. The dose-effect relationship between irradiation dose and red blood cell damage degree is clarified, providing experimental evidence for the safe dose of irradiation processing of autologous blood during surgery. |
| Who can participate | Inclusion Criteria: * Patients scheduled for elective surgery for malignant tumors * Age: 18 - 65 years old * It is estimated that the surgical bleeding will be greater than or equal to 500 milliliters. Exclusion Criteria: * Disorders of red blood cell production (such as aplastic anemia, megaloblastic anemia, iron deficiency anemia, leukemia, myelofibrosis, etc.) * Diseases caused by increased destruction of red blood cells (abnormalities in red blood cell membranes such as hereditary spherocytosis and paroxysmal nocturnal hemoglobinuria; abnormalities in hemoglobin such as thalassemia; abnormalities in red blood cell-related enzymes such as glucose-6-phosphate dehydrogenase deficiency, etc.) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Lead sponsor | Second Affiliated Hospital, School of Medicine, Zhejiang University |
| Locations | Hangzhou, Zhejiang, China |
| Start date | 2026-01-28 |
| NCT ID | NCT07416045 |
| Official listing | https://clinicaltrials.gov/study/NCT07416045 |