A Multimodal Study of the Relationship Between Exposure to Endocrine Disruptors and Occurr
This study aims to demonstrate the impact of Endocrine-Disrupting Chemicals (EDCs) on the risk of hypospadias incidence. It is a multicenter comparative case-control study, involving two groups. The first group consists of biological mothers who have given birth to children with hypospadias (Case Group), while the seco
| Condition(s) | Hypospadias |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | This study aims to demonstrate the impact of Endocrine-Disrupting Chemicals (EDCs) on the risk of hypospadias incidence. It is a multicenter comparative case-control study, involving two groups. The first group consists of biological mothers who have given birth to children with hypospadias (Case Group), while the second group consists of biological mothers who have given birth to children without any malformations (Control Group). Through an integrative approach that combines a direct toxicological study of numerous pollutants present during pregnancy, and a comprehensive exposome assessment using validated tools, this study can significantly enhance our understanding and prevention of this malformation. |
| Who can participate | Non-specific Inclusion Criteria : * Parents of legal age having signed a free and informed consent for the participation of their child * Biological mother of a boy aged between 1 and 6 months * Biological mother with a minimum hair length of 18 cm * Biological mother who has signed a free and informed consent for her participation * Biological mother and child affiliated with or beneficiaries of a national health insurance plan * Biological mother who is fluent in written and spoken French Specific Inclusion Criteria for Case Group: \- The child has an isolated anterior or middle hypospadias, without any other complex variations of genital development (borderline penile size, unilateral or bilateral cryptorchidism, retractile testes), without malformation syndrome and without identified g |
| Ages | 1 Month |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | University Hospital, Montpellier |
| Locations | Montpellier, Hérault, France |
| Start date | 2024-10-03 |
| NCT ID | NCT06628375 |
| Official listing | https://clinicaltrials.gov/study/NCT06628375 |