A Muscle-brain Interplay Study in Neurological Disorders
Despite the improvements in life expectancy, neurodegenerative diseases (NDGs) have become the most dreaded disorders of older people. Aged brains show characteristic changes that are linked to neurodegeneration raising the question of whether these hallmarks represent the harbingers of NDGs. Lifestyle factors includin
| Condition(s) | Neurological Disorders, Health Adult Subjects |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | Despite the improvements in life expectancy, neurodegenerative diseases (NDGs) have become the most dreaded disorders of older people. Aged brains show characteristic changes that are linked to neurodegeneration raising the question of whether these hallmarks represent the harbingers of NDGs. Lifestyle factors including, in particular physical exercise, have given particular attention to factors associated to movement issue as ones of the major factors in modulating the risk of developing NDGs, emphasizing the interest in the muscle-brain axis. Indeed, one of the crucial systems severely affected in several neuromuscular diseases is the loss of effective connection between muscle and nerve, and the neuromuscular junction (NMJ) represents the critical region at the level of which the two en |
| Who can participate | Inclusion Criteria: for Good aging group: * Subjects aged 60 years or older * Frailty Index below the pathological cut-off (\>0.25) * Absence of general cognitive impairment (MMSE \> 24 points) * Absence of a diagnosis of sarcopenia for Bad aging group: * Patients aged over 60 years * Exclusive presence of one of the following diagnoses: 1. Definite, probable, or probable laboratory-supported Amyotrophic Lateral Sclerosis (ALS), either sporadic or familial, according to the revised El Escorial Criteria for ALS diagnosis. 2. Parkinson's disease (PD) according to the MDS Clinical Diagnostic Criteria for Parkinson's Disease (Postuma et al., Mov Disord., 2015 Oct; 30(12): 1591-1601). 3. Alzheimer's disease (AD), possible or probable, according to international diagnostic guidelines. 4. Diagnos |
| Ages | 60 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | Istituti Clinici Scientifici Maugeri SpA |
| Locations | Catania, Italy; Messina, Italy; Milan, Italy; Roma, Italy |
| Start date | 2025-07-24 |
| NCT ID | NCT07477821 |
| Official listing | https://clinicaltrials.gov/study/NCT07477821 |