A Randomised Controlled Trial on the Networks Integrating Anxiety and Metabolism in Anorex
Anorexia nervosa (AN) is known as the psychiatric disorder with the highest mortality rate as long-term calorie restriction causes medical complications and suicide risk. The ineffectiveness of pharmacological treatments increases interest in the etiopathogenesis of the disease. This study aims to examine the effects o
| Condition(s) | Anorexia Nervosa |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | Anorexia nervosa (AN) is known as the psychiatric disorder with the highest mortality rate as long-term calorie restriction causes medical complications and suicide risk. The ineffectiveness of pharmacological treatments increases interest in the etiopathogenesis of the disease. This study aims to examine the effects of caloric and non-caloric food intake on stress response, changes in brain network activity in AN patients and healthy volunteers, and examine whether these changes are related to caloric intake through neuroendocrine and psychological responses. The study will include 30 female AN patients aged 13-18 who are newly diagnosed and have not received any treatment, and 30 healthy volunteers matched by age, sex, and education level. The patient group will be admitted to the clinic |
| Who can participate | Inclusion criteria: * Female individuals * 13-18 years of age * Currently patients at the eating disorder clinic * Newly diagnosed with AN according to the Diagnostic and Statistical Manual of mental disorders 5th edition (DSM-5) * Treatment naïve Healthy control participants will be matched on age-, sex-, and education level with the AN-participants. The clinical diagnosis/diagnoses for participants will be validated/ruled out by the Structured Clinical Interview for DSM-5 (SCID-5). The presence of other exclusion criteria will also be further explored at the clinical visit. Exclusion criteria: * Having one or several chronic medical conditions that may interfere with or hinder participation, or affect study outcomes. * Use of medications that affect hormone levels or eating behaviors. * |
| Ages | 13 Years to 18 Years |
| Sex | Female |
| Accepts healthy volunteers | Yes |
| Lead sponsor | Umeå University |
| Locations | Izmir, Turkey (Türkiye) |
| Start date | 2025-02-15 |
| NCT ID | NCT06814002 |
| Official listing | https://clinicaltrials.gov/study/NCT06814002 |