A Study to Investigate Why Overweight People Regain Weight After Losing Weight in a Behavi
The goal of this clinical trial is to determine the physiological basis for the differences in weight regain among adults (25-59 years old) with obesity following participation in a behavioral weight loss program. Eligible participants will undergo a baseline evaluation after which they will enter an up to 20 week beha
| Condition(s) | Obesity |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | The goal of this clinical trial is to determine the physiological basis for the differences in weight regain among adults (25-59 years old) with obesity following participation in a behavioral weight loss program. Eligible participants will undergo a baseline evaluation after which they will enter an up to 20 week behavioral weight loss program with the goal of losing at least 7 percent of their baseline weight within 35 weeks. Participants who meet the weight loss goal will be asked to remain weight stable for 2 weeks after which they will undergo a clinical examination. They will then be observed for 1 year during which they will undergo 2 additional clinical examinations, one 4 months after completing the weight loss program, and the other 12 months after completing the weight loss prog |
| Who can participate | Inclusion Criteria: 1. Age: 25 - \<60 years 2. BMI: 30 - \<40 kg/m2 at the first screening visit 3. Within 5% of current weight, for the past 6 months at the first screening visit 4. Able to participate in ergometry testing 5. Has a smart phone, tablet or computer with access to the internet Exclusion Criteria: 1. If 25-29 years old, \> 5% deviation from maximum weight (excluding weights while pregnant) since age 25 years 2. If at least 30 years old, \> 5% deviation from maximum weight (excluding weights while pregnant) in last 5 years or ≥ 10% deviation from maximum weight (excluding weights while pregnant) since age 30 years 3. History of pulmonary embolus in the past 6 months 4. Cardiovascular disease (e.g. myocardial infarction, stroke, hospitalization for unstable angina, or transient |
| Ages | 25 Years to 59 Years |
| Sex | All |
| Lead sponsor | University of Pittsburgh |
| Locations | New York, New York, United States; Philadelphia, Pennsylvania, United States; Philadelphia, Pennsylvania, United States |
| Start date | 2023-09-29 |
| NCT ID | NCT05748158 |
| Official listing | https://clinicaltrials.gov/study/NCT05748158 |