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A Trial of Varenicline for E-cigarette Cessation

This is randomized, placebo-controlled clinical trial in treatment-seeking adults who report regular e-cigarette use to test the hypothesis that varenicline is efficacious for quitting e-cigarettes.

Condition(s)E-cigarette Use, Vaping, Nicotine Dependence
StatusRecruiting
PhasePhase 2
Study typeInterventional
SummaryThis is randomized, placebo-controlled clinical trial in treatment-seeking adults who report regular e-cigarette use to test the hypothesis that varenicline is efficacious for quitting e-cigarettes.
Who can participateInclusion Criteria: * report daily use of an e-cigarette containing nicotine * live in Connecticut or South Carolina Exclusion Criteria: * regular use of other tobacco products besides e-cigarettes * medical contraindications for varenicline use * current treatment for tobacco cessation * lack proficiency in English
Ages18 Years
SexAll
Lead sponsorYale University
LocationsNew Haven, Connecticut, United States; Charleston, South Carolina, United States
Start date2025-10-14
NCT IDNCT07040566
Official listinghttps://clinicaltrials.gov/study/NCT07040566

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