A VIRTUAL Three-month Intervention Study of the Effects of a Smartphone Application (Hippo
Down syndrome is a chromosomal abnormality associated with significant deficits across multiple cognitive domains, including a disproportionate deficit in hippocampally-dependent memory. In other words, individuals with Down syndrome may have a particular difficulty remembering specific details from past events. One wa
| Condition(s) | Memory Replay, HippoCamera |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | Down syndrome is a chromosomal abnormality associated with significant deficits across multiple cognitive domains, including a disproportionate deficit in hippocampally-dependent memory. In other words, individuals with Down syndrome may have a particular difficulty remembering specific details from past events. One way this manifests itself is in overgeneral autobiographical memory, or a tendency to remember the general gist of an event or cluster of events, rather than a single, isolated event. This overgeneral memory makes it difficult for individuals with Down syndrome to access their past, can interfere with attempts to becoming more independent, and increases anxiety and depression. In the current VIRTUAL study, the investigators test whether a new digital memory prosthetic-HippoCame |
| Who can participate | Inclusion Criteria: * Diagnosis of Down syndrome * Daily access to a smart phone * The ability to create and replay memories using HippoCamera with limited support from a guardian * Informed consent obtained from parent or guardian (or participant, if legally independent) * Informed verbal assent obtained from participant * Ability to comprehend instructions, denoted by parent/guardian acknowledgment * English as a primary written and spoken language * Normal or corrected-to-normal vision and hearing * All races/ethnicities and socio-economic statuses Exclusion Criteria: * Autism * Non-native speaker of English (acquired after the age of 5) |
| Ages | 15 Years to 35 Years |
| Sex | All |
| Lead sponsor | Boston College |
| Locations | Chestnut Hill, Massachusetts, United States |
| Start date | 2025-06-01 |
| NCT ID | NCT07008989 |
| Official listing | https://clinicaltrials.gov/study/NCT07008989 |