Aberrant Synaptic Plasticity in Cocaine Use Disorder: A 11C-UCB-J PET Study
The purpose of this research study is to measure synaptic density in the brain comparing individuals with cocaine use disorder to healthy controls.
| Condition(s) | Cocaine Use Disorder, Healthy Controls |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | The purpose of this research study is to measure synaptic density in the brain comparing individuals with cocaine use disorder to healthy controls. |
| Who can participate | Inclusion Criteria: * Age 21-60 years * Physically healthy by medical history, physical, neurological, ECG and laboratory examinations * For females, a negative serum pregnancy test * For CUD: DSM-5 criteria for Cocaine Use Disorder and positive urine toxicology showing recent use * For HC: Negative urine toxicology Exclusion Criteria: * DSM-5 criteria for other substance use disorders (e.g., alcohol, opiates, sedative hypnotics), except for nicotine * A primary DSM-5 Axis I major psychiatric disorder (e.g., schizophrenia, bipolar disorder, major depression, etc.) as determined by the Structured Clinical Interview for DSM-5 (SCID-5) * A history of significant and/or uncontrolled medical or neurological illness * Current use of psychotropic and/or potentially psychoactive prescription medic |
| Ages | 21 Years to 60 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | Yale University |
| Locations | New Haven, Connecticut, United States |
| Start date | 2021-07-20 |
| NCT ID | NCT04721418 |
| Official listing | https://clinicaltrials.gov/study/NCT04721418 |