Achieving nuTritional Target in criticAlly Ill patieNts With iMpairEd gastroiNtesTinal Dys
Clear study hypothesis / research question It has already been proven that a prolonged negative energy balance during intensive care stay is an independent risk factor for mortality. Although it was thought that achivieng optimal delivery of calories will prevent nutritional deficits in critically ill patients, publish
| Condition(s) | Parenteral Nutrition, Gastroparesis, Gastrointestinal Dysfunction, Protein Deficiency, Critical Illness |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | Clear study hypothesis / research question It has already been proven that a prolonged negative energy balance during intensive care stay is an independent risk factor for mortality. Although it was thought that achivieng optimal delivery of calories will prevent nutritional deficits in critically ill patients, published randomized controlled trials failed to confirm this hypothesis. Combinging enteral and parenteral support may be an efficent strategy to reach nutritional target in critically ill patients. According to the current guidelines the use of suplemental parenteral nutrition (SPN) should be considered when energy targets are not achieved by enteral (EN) route, however, no clear data regarding timing, amount and composition is specified. Moreover, based on recente published data |
| Who can participate | Inclusion Criteria: * All adults (\> 18 years old) * Mechanical ventilation for more than four days, * Controlled shock state (hemodynamic and tissue perfusion goals are reached) - Impaired intestinal absorbtion, defiend by both ultrasound measurement of gastric residual volume and paracetamol absorbtion test Exclusion Criteria: * patients on non-invasive mechanichal ventilation * contraindication for EN for \> 48 h after admission * patients with gastrointestinal surgical intervention within 3 months, * history of malabsorption, inflammatory bowel disease * short bowel syndrom * anorexia nervosa * gastrointestinal bleeding * cirrhosis * traumatic brain injury * subarahnoidal hemorrhage * neoplasia * post cardiac arrest patients * patients on chronic therapy with corticosteroids * pregnant |
| Ages | 18 Years |
| Sex | All |
| Lead sponsor | Romanian Society for Enteral and Parenteral Nutrition |
| Locations | Bucharest, Romania |
| Start date | 2024-10-01 |
| NCT ID | NCT06510348 |
| Official listing | https://clinicaltrials.gov/study/NCT06510348 |