Aerobic Exercise and Its Impact on Sensory, Musculoskeletal, and Psychosocial Aspects in M
Migraine is a neurological disorder associated with high levels of disability and changes in sensory processing, musculoskeletal function, and psychosocial factors. Aerobic exercise is a low-cost, non-pharmacological strategy that has shown potential benefits for migraine management, but its effects on sensory percepti
| Condition(s) | Migraine, Migraine Disease, Migraine Disorder, Migraine Disorders, Brain, Headache, Headache (Migraine), Headache Disorders, Headache Disorders, Primary, Aerobic Exercise, Pain Management, Sensory Dis |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | Migraine is a neurological disorder associated with high levels of disability and changes in sensory processing, musculoskeletal function, and psychosocial factors. Aerobic exercise is a low-cost, non-pharmacological strategy that has shown potential benefits for migraine management, but its effects on sensory perception and musculoskeletal function are not yet fully understood. This randomized controlled trial will investigate the effects of a supervised aerobic exercise program combined with pain neuroscience education compared with an active control condition in women aged 18 to 48 years diagnosed with migraine. Participants will be randomly allocated to either an intervention group, which will perform supervised aerobic exercise three times per week for 16 weeks and receive one session |
| Who can participate | Inclusion Criteria: * Women aged between 18 and 48 years. * Diagnosed with migraine by an experienced neurologist specialized in headaches, following the criteria of the International Classification of Headache Disorders (ICHD). * Frequency of headache between 3 and 8 days per month, to ensure adherence to the treatment. Exclusion Criteria: * Presence of any other type of concurrent headache. * Medical conditions affecting sensitivity and autonomic modulation, such as peripheral neuropathies, autonomic disorders, severe neurological diseases, and others. * Conditions that prevent physical activity, such as severe musculoskeletal injuries, cardiovascular diseases, or related conditions. * Premature ovarian failure. * Regular physical exercise in the past year. * Body Mass Index (BMI) above |
| Ages | 18 Years to 48 Years |
| Sex | Female |
| Lead sponsor | University of Sao Paulo |
| Locations | Ribeirão Preto, São Paulo, Brazil |
| Start date | 2026-03-03 |
| NCT ID | NCT06716489 |
| Official listing | https://clinicaltrials.gov/study/NCT06716489 |