Amplification of Positivity for Alcohol Use
The proposed study consists of two phases. During Phase 1, the investigators will recruit a small sample of participants to complete a psychosocial intervention termed Amplification of Positivity (AMP) for individuals experiencing comorbid depression or anxiety disorders and alcohol use disorder (AMP-A). These particip
| Condition(s) | Alcohol Use Disorder, Anxiety, Depression |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | The proposed study consists of two phases. During Phase 1, the investigators will recruit a small sample of participants to complete a psychosocial intervention termed Amplification of Positivity (AMP) for individuals experiencing comorbid depression or anxiety disorders and alcohol use disorder (AMP-A). These participants will be asked to provide both qualitative and quantitative input about the AMP-A intervention. Based on their input and clinician input, the AMP-A manual will be modified for use in Phase 2. The goal is to recruit up to 20 participants in order to ensure there will be at least 8 participants who complete all sessions of AMP-A. Phase 2 is a randomized clinical trial (RCT) protocol in which individuals experiencing comorbid depression or anxiety disorders and alcohol use d |
| Who can participate | Inclusion Criteria: 1. Age between 18 and 65 years old. 2. Meeting diagnostic criteria for alcohol use disorder 42 according to the DSM-5. 3. Reports that they would like to seek treatment for AUD and that AUD is one of the primary challenges they would like to address in treatment. 4. Phase 1: Significant depression or anxiety symptoms as indexed by scoring Patient Health Questionnaire (PHQ-9) ≥ 10 and/or Overall Anxiety Severity and Impairment Scale (OASIS) ≥ 8. Phase 2: Significant depression or anxiety symptoms as indexed by scoring ≥ 55 on either of the NIH PROMIS ((Patient-Reported Outcomes Measurement Information System) Depression and/or Anxiety scales. 5. Below normative levels of positive affect as indexed by PROMIS Positive Affect \<50. 6. Able to provide written informed consen |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Lead sponsor | Laureate Institute for Brain Research, Inc. |
| Locations | Tulsa, Oklahoma, United States |
| Start date | 2023-09-25 |
| NCT ID | NCT06030154 |
| Official listing | https://clinicaltrials.gov/study/NCT06030154 |