Amygdala MRI-TIS for Depression
The study utilizes a non-invasive deep brain stimulation (temporal interference, TI) technique primarily targeting the amygdala to preliminarily explore the clinical efficacy and potential mechanisms of MRI-compatible TI technology in regulating the amygdala in depressive disorders, providing a more comprehensive basis
| Condition(s) | Major Depressive Disorder |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | The study utilizes a non-invasive deep brain stimulation (temporal interference, TI) technique primarily targeting the amygdala to preliminarily explore the clinical efficacy and potential mechanisms of MRI-compatible TI technology in regulating the amygdala in depressive disorders, providing a more comprehensive basis for the application of TI technology. |
| Who can participate | Inclusion Criteria: * Participants must be aged between 18 and 65, with no gender restrictions; * A diagnosis of depression made by the study physician based on the Diagnostic and Statistical Manual of Mental Disorders (DSM-5); * HAMD-17 score of 17 or higher; * Participants must not have changed their antidepressant medication regimen from 30 days prior to signing the informed consent form through the duration of the experiment; * Eligible individuals or their authorized representatives must demonstrate, as assessed by the study physician, a comprehensive understanding of the study's objectives and procedures, be capable of adhering to the requirements set forth in the study protocol, and provide their signature on the informed consent form. Exclusion Criteria: * Eligible participants mus |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Lead sponsor | Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University |
| Locations | Shanghai, Shanghai Municipality, China |
| Start date | 2024-05-27 |
| NCT ID | NCT06461260 |
| Official listing | https://clinicaltrials.gov/study/NCT06461260 |